CJC-1295 DAC vs No DAC: How CJC-1295 With and Without DAC Differ

CJC-1295 DAC vs No DAC Side by Side

What the DAC Actually Does

Native growth hormone releasing hormone is broken down within minutes by dipeptidyl peptidase-4, which clips the first two residues. Mod GRF (1-29) fixes that with four amino acid substitutions, at positions 2, 8, 15 and 27, which make the chain far more resistant to enzymes and to oxidation. That alone stretches the half-life to around half an hour.

CJC-1295 with DAC goes further. A lysine added to the end of the chain carries a reactive maleimide group, the drug affinity complex. Once in plasma it forms a covalent bond with a free cysteine on serum albumin, and the peptide then circulates attached to a protein that lasts for weeks. In the 2006 human studies by Teichman and colleagues, a single dose raised mean GH levels several-fold for six days or more and IGF-1 for well over a week, with an estimated half-life of 5.8 to 8.1 days. A follow-up by Ionescu and Frohman reported that GH pulses were preserved while trough levels rose.

Why the Names Get Confused

Strictly, "CJC-1295" was the development code for the DAC molecule. The market has since adopted "CJC-1295 no DAC" as a second name for Mod GRF (1-29), so the same three words now describe two different compounds. Before you buy CJC-1295 for a protocol, check which one the paper used. Look for the phrase "drug affinity complex", a half-life measured in days, or dosing intervals of a week or more: all three point to the DAC version. Papers on pulsatile GH release, short sampling windows or blends with a GHRP almost always mean Mod GRF.

Our listings follow that split. The CJC-1295 no DAC 10 mg vial is Mod GRF (1-29). The CJC-1295 DAC 5 mg vial is the albumin-binding form. Each label states the version, and the certificate of analysis confirms identity by mass, which separates the two cleanly because the DAC adds roughly 280 g/mol.

Choosing CJC-1295 With or Without DAC for Your Study Design

Our view: start from the sampling schedule, not the compound. If you plan to sample GH every 10 to 20 minutes and want to see discrete pulses, the DAC version will flatten your baseline for a week and blur the signal, so Mod GRF is the better tool. If your endpoint is IGF-1 or another slow marker measured over days, the DAC version gives a steadier exposure from fewer administrations.

Washout matters more than most protocols allow for. With a multi-day half-life, a DAC arm needs weeks before baseline returns, which makes crossover studies slow.

How They Compare With Other GHRH Analogues

Both versions sit in the same family as sermorelin, which is the unmodified GHRH (1-29) sequence with a half-life of minutes, and tesamorelin, a full-length GHRH (1-44) analogue stabilised with a trans-3-hexenoyl group at the N-terminus. Sermorelin is the reference point for native-like pulsatile signalling, Mod GRF is its more stable cousin, tesamorelin is the most studied clinically, and CJC-1295 with DAC is the long-acting outlier. You can see all four together in our growth hormone peptides range.

Pairing CJC-1295 With Ipamorelin

GHRH analogues and ghrelin receptor agonists act on different receptors on the same pituitary cells, and the two signals add together. Ipamorelin is the GHRP most often paired with Mod GRF because it is selective for GH release, with little effect on cortisol or prolactin in the published work. Because both are short-acting, their timing lines up. If your protocol uses a fixed ratio, our CJC-1295 and ipamorelin blend holds 5 mg of each in one 10 mg vial. For dose-response work, buy separate vials so each compound can be varied on its own. The human study record for both is summarised in our guide to CJC-1295 and ipamorelin side effects.

Reconstitution and Storage

Both forms are supplied as lyophilised powder. Reconstitute with bacteriostatic water, adding it slowly down the vial wall and swirling rather than shaking; our peptide reconstitution guide walks through it step by step. The CJC-1295 and ipamorelin calculator works out concentration and syringe units for any fill, and insulin syringes make small volumes easier to measure. Keep dry vials frozen and protected from light, and refrigerated once mixed, as set out in the peptide storage guide. When you receive a vial, compare its lot number with the COA; our guide to reading a certificate of analysis explains what to check.

Order CJC-1295 With or Without DAC Online in Australia

Once the half-life question is settled, picking a vial is quick. CJC-1295 No DAC, the Mod GRF (1-29) form, comes as a 10 mg vial at $79, and CJC-1295 With DAC as a 5 mg vial, also $79. Pulsatile study designs should buy the No DAC form; work that needs sustained GHRH receptor exposure from infrequent additions should buy the DAC version. For fixed-ratio work with a ghrelin receptor agonist, the CJC-1295 and ipamorelin blend saves preparing two vials. All three are held in Australian stock, every lot is checked by an independent laboratory, and the certificates sit in our COA library. Shop the growth hormone peptide range online and add bacteriostatic water to the same order.

All CJC-1295 products are sold for laboratory research use only. They are not approved by the TGA and are not for human or veterinary use.