MOTS-c Australia: Buy MOTS-c Online

MOTS-c Australia Lot Data for the 10 mg, 20 mg and 40 mg Vials

Shop MOTS-c for work on signalling between mitochondria and the nucleus, in the size that matches how fast your lab will use it. All three fills share one specification and one release test.

What Is MOTS-c?

MOTS-c is a small peptide that mitochondria build themselves and send out as a signal, telling the rest of the cell how its energy supply is faring. That one line covers the reason the compound exists in catalogues: it is a messenger from an organelle that was assumed to have nothing to say.

A little background makes the oddity clear. Human cells keep nearly all their genes in the nucleus, but mitochondria hold their own small circular genome of about 16,500 base pairs, a leftover from the bacterial ancestor they descend from. Textbooks credited that genome with 37 genes, 13 of them proteins, all of which stay inside the organelle. The MOTS-c reading frame hides inside one of the others, the stretch coding 12S ribosomal RNA, overlapping a sequence whose job was supposed to be structural. Reading it out requires the mitochondrial genetic code, which differs from the nuclear one, so the peptide was overlooked by the standard gene-finding tools of the day.

MOTS-c at a glance

• 16 residues, MRWQEMGYIFYPRKLR, encoded in mitochondrial rather than nuclear DNA.
• Second of the mitochondrial-derived peptides to be described, following humanin in 2003.
• Two methionine residues, which makes oxidation the handling risk to design around.
• Listed in the metabolic modulators class of the current anti-doping prohibited list.

Genetics gives the most striking evidence that the peptide matters. Zempo and colleagues, writing in Aging in 2021, examined a mitochondrial DNA variant found in East Asian populations, m.1382A to C, which changes residue 14 of the peptide from lysine to glutamine. In a large Japanese cohort the variant tracked with type 2 diabetes prevalence in men, and only in those reporting the least physical activity. The altered peptide also performed worse than the usual form in their mouse and cell experiments. A single base change in mitochondrial DNA, altering one residue in a 16-residue peptide, with a measurable association in a population: that is a stronger argument for biological relevance than any supplementation study.

For labs, our advice is to treat the variant as the experiment rather than an aside. Ordering the standard sequence and a K14Q version synthesised to match gives a built-in specificity control, and any response seen with both points away from the mechanism under test. Dig into the published cell and rodent findings in our review of what MOTS-c research has measured before settling on endpoints, because the effects reported are mostly indirect and need a readout chosen with care.

Buy MOTS-c Peptide Online in Australia, the Mitochondria-Encoded Signal

Almost every peptide in our catalogue is coded by nuclear genes, and MOTS-c is the exception. Its sequence sits in the small circular genome inside mitochondria, which places it among the mitochondrial-derived peptides alongside humanin. A University of Southern California team led by Changhan Lee first described it in Cell Metabolism in 2015, reporting that it acted mainly in skeletal muscle by switching on AMPK, the cell's energy sensor. Our guide to MOTS-c benefits in published cell and rodent work follows that record forward.

Order it to explore a specific question. How does a signal written in mitochondrial DNA reach and influence nuclear gene expression? This vial is a research reagent for studying that in cells, with no link to any approved medicine, and the mitochondrial peptides category lists the compounds usually ordered with it.

Where MOTS-c Stands in Australia, and What Each Vial Contains

All three fills arrive the same way: a sealed glass vial holding a white freeze-dried cake of the 16-residue peptide, with no second compound added. The 10 mg and 40 mg vials wear amber flip-off caps, which makes them easy to tell apart from green-capped vials such as tirzepatide on a shared freezer shelf. The 20 mg fill sits between them for labs that find 10 mg too small and 40 mg too much to use in time.

MOTS-c began as a discovery rather than a drug design. The 2015 Cell Metabolism report came from a search of the mitochondrial genome for short open reading frames that might encode signalling peptides, and the 12S rRNA region turned one up. As of October 2026 no product containing MOTS-c is registered on the ARTG and no regulator we know of has approved it as a medicine, so the vial on this page is a laboratory reagent with no prescription equivalent.

MOTS-c and the WADA Prohibited List

Sport is where this peptide now has a formal status. WADA's 2025 Prohibited List named MOTS-c as an example of an AMP-activated protein kinase activator within the metabolic modulators class, S4, which is banned in and out of competition. Sport Integrity Australia applies the same list here, so MOTS-c is a prohibited substance for any athlete subject to the code.

For research groups, MOTS-c for sale in Australia means reagent supply. AminoBlend holds the 10, 20 and 40 mg vials in Australian stock, available to order online by adults 18 and over, for in vitro use only and never for human or veterinary use. Labs that buy MOTS-c in Australia as part of an ageing biology programme will find related compounds in the longevity peptides range.

Shop MOTS-c Australia Stock in Three Sizes With Lot Tracking

Buy the 10 mg vial at $69, or $6.90 per milligram, for first orders, pilot runs and short concentration-response series, since it is the easiest to finish within 28 days of mixing. The 20 mg vial at $119, or $5.95 per milligram, covers two or three short experiments. The 40 mg vial at $189, about $4.73 per milligram, suits a settled method that will use the whole solution in time.

Order more than one vial together and request a single lot wherever stock allows, so one certificate documents the entire series. Checkout is limited to adults 18 and over.

Size choice comes down to the 28 day window more than to price. A 40 mg vial that is only half used before the solution expires costs more per useful milligram than two 10 mg vials opened a month apart, so match the fill to the pace of your experiments rather than to the lowest sticker figure.

Order MOTS-c in Stock With Structure, Purity and Lot Certificate

The sequence carries two methionines, which makes it worth protecting from oxidation, and a cluster of basic arginine and lysine residues near the C-terminus. Published work links that basic tail to its movement into the nucleus under metabolic stress, reported by the same group in 2018. A 2021 Nature Communications study then tied its levels to exercise, with work in aged mice, and that is the thread most current cell models follow.

The best MOTS c peptide for bench work is one whose certificate you can check. Look for a measured mass close to 2174.6 g/mol, the sequence MRWQEMGYIFYPRKLR and the HPLC purity for your lot, all published in the COA library under the lot code printed on the vial.

Buy MOTS-c Near You, Then Mix and Store the Vial

We have no storefront. The business runs online and ships from Australian stock to every state, so each MOTS-c Australia order, whether bound for a lab buying peptides in Adelaide, Cairns or a farm postcode, comes from the same shelf. A cleared payment before 3pm on a business day means same-day dispatch, as the delivery information page explains.

Order bacteriostatic water with the vial, because it holds only the dry peptide. Bring it to room temperature, add the water slowly against the glass and swirl rather than shake. Two mL in the 10 mg vial gives 5 mg/mL, and the MOTS-c reconstitution calculator covers the 20 and 40 mg fills or any other volume.

Hold unopened MOTS-c vials frozen at -20 °C. After mixing, hold the solution at 2 to 8 °C, away from light, in aliquots so no portion is thawed more than once, and limit air exposure because of the methionines.

Other Names for MOTS-c

Labels and papers write it as MOTS-c, MOTS-C, MOTS C or MOT-C, an acronym built from the open reading frame it comes from, a short coding stretch inside the mitochondrial 12S rRNA gene, type c. It belongs to the mitochondrial-derived peptides, sometimes abbreviated MDPs, and is identified by CAS 1627580-64-6.

Related vocabulary includes AMPK (AMP-activated protein kinase), the folate cycle and AICAR, an intermediate the 2015 paper linked to its action. None of these are separate products, as they describe the pathway the peptide is studied in.

Shop the Best Peptides to Stack With MOTS-c in a Mitochondrial Design

The best peptide to stack with MOTS c depends on the level of mitochondrial biology you want to probe. MOTS-c is a signalling peptide that acts through AMPK and gene expression, while SS-31 is a synthetic tetrapeptide that binds cardiolipin in the inner mitochondrial membrane. Choose MOTS-c for signalling questions, SS-31 for membrane and bioenergetics questions, and separate vials of both to keep their contributions apart.

Buy NAD+ when the coenzyme at the centre of energy metabolism belongs in the design, or SLU-PP-332, a small molecule that switches on estrogen-related receptors, for a non-peptide route into the same mitochondrial programmes.