PT 141 Peptide Australia: Buy PT-141 Online or as a Nasal Spray

Shop PT 141 Peptide in a 10 mg Vial or 10 mL Spray With Full Lot Data

Buy PT-141 when a study needs a melanocortin ligand that leans toward the central receptors rather than the broad profile of Melanotan 2. Both formats are on the shelf, every lot ships with its own HPLC report, and the melanocortin range lists related compounds to compare before you check out.

What Is PT 141?

PT-141, known in the clinical literature as bremelanotide, is a small ring-shaped lab-made peptide that activates melanocortin receptors in the brain, the MC4 receptor above all, a pathway tied to sexual motivation and appetite. It acts on brain circuits rather than on blood vessels, and that distinction matters more than any other detail about it.

The melanocortin system in brief

In the arcuate nucleus of the hypothalamus, a group of neurons makes a large precursor protein called POMC and cuts it into smaller signals, one of them alpha-MSH. Alpha-MSH reaches five melanocortin receptors, numbered MC1R to MC5R, and all five couple to Gs and lift cyclic AMP. MC1R sits on pigment cells in skin. MC3R and MC4R are concentrated in the brain, and MC4R in particular sits on neurons in the paraventricular nucleus that weigh energy status and other drives. The system also has its own built-in brake, agouti-related peptide, released by a neighbouring set of neurons to block the same receptor. The weight of MC4R in physiology shows up in human genetics: faulty copies of the MC4R gene are the most common single-gene cause of severe early-onset obesity.

That sets PT-141 apart from the vascular drugs most people compare it with. Phosphodiesterase 5 inhibitors act on smooth muscle in the blood vessels and need a signal already under way. The PT 141 peptide works further upstream, in the circuits that generate the drive in the first place.

What the clinical programme measured

Approval rested on RECONNECT, two identical phase 3 trials published in Obstetrics and Gynecology in 2019 with Sheryl Kingsberg as lead author. Across the pair, 1,267 premenopausal women with hypoactive sexual desire disorder were randomised to bremelanotide or placebo for 24 weeks. The coprimary endpoints were questionnaire scores for desire and for related distress, and those results supported US approval later that year. Nausea was the most frequently reported adverse event.

For a laboratory, our recommendation is to treat bremelanotide as an MC4R-leaning tool rather than a pure one. It still binds MC1R and MC3R, so receptor attribution needs either a cell line expressing a single receptor subtype or a selective antagonist alongside it. Readers comparing it with its two Arizona relatives will find all three set out in our full guide comparing bremelanotide with both Melanotan peptides.

Buy PT-141 Online in Australia as a Ligand Built From Melanotan 2

PT-141 came out of 1990s work on Melanotan 2. Swapping the C-terminal amide of that cyclic peptide for a free carboxylic acid gave bremelanotide, a molecule with the same ring and a different receptor balance. Order it when the bench question is narrow, namely what happens when the MC3 and MC4 receptors, both dense in the hypothalamus and brainstem, are activated with less pull on the MC1 pigment receptor.

Shop it for binding and cAMP assays in transfected cell lines, for mapping melanocortin circuits in rodent tissue and for cardiovascular readouts in animal models. A formulated version of bremelanotide gained United States approval in 2019 under the name Vyleesi. AminoBlend does not sell or represent that medicine, and everything offered on this page is a research reagent.

PT-141 Australia Status: Vyleesi Overseas, Research Stock Here

Two physical products share this listing. The vial is a white-capped glass vial with a pink and blue label holding 10 mg of bremelanotide as a lyophilised white powder, while the spray is a 10 mL bottle of pre-dissolved solution fitted with a white pump actuator and a silver collar. Palatin Technologies of New Jersey developed the compound, using the name Rekynda for a time, licensed North American rights to AMAG Pharmaceuticals in 2017, and the US FDA approved AMAG's application on 21 June 2019. The approved product, Vyleesi, is a prefilled autoinjector for one narrow indication in premenopausal women, and it is now marketed in the United States by Cosette Pharmaceuticals.

Australia never followed. When we queried the TGA's PI and CMI database in October 2026, bremelanotide and Vyleesi returned nothing, and we found no ARTG registration, so no pharmacy here can fill a script for it. Its legal status is less tidy than its parent's. The Poisons Standard (June 2026 instrument) names Melanotan II in Schedule 4 but contains no entry using the name bremelanotide or PT-141, and the TGA has not published a scheduling decision on it that we could find. We read that as an open question, not as permission, and the TGA's repeated warnings about melanotan products show how closely it watches this receptor class.

Why do research suppliers carry it at all? Because bremelanotide is a well-characterised MC3R and MC4R ligand with a published clinical record, and with no registered product in the country, a research supplier is the only route for an Australian lab that wants to buy PT-141 as a weighed quantity. We keep PT 141 for sale in Australia in both formats, as reagents for laboratory use only; purchasers must be 18 or over, and neither the vial nor the spray is for people or animals. Our Melanotan 1, Melanotan II and PT-141 comparison sets the three melanocortin peptides side by side.

Order the Best PT 141 Peptide Format for Your Lab

Two formats carry one molecule. The 10 mg vial at $59 comes to $5.90 per milligram and lets you set the concentration yourself, which suits receptor assays and any method needing an unusual strength. The 10 mL nasal spray at $69 arrives already dissolved at a strength fixed during manufacture, so it fits formulation comparisons and protocols that specify a bottled liquid. Most labs choose the vial, because the extra $10 on the spray buys convenience rather than more peptide.

Order every vial for a long series in one cart so they leave from a single lot wherever stock allows under one certificate. That keeps the analytical record identical from the first experiment to the last. Checkout asks each buyer to confirm they are 18 or older, and orders are accepted on that basis alone.

Shop Lot-Tested PT-141 With a Verified Structure

A lactam bridge between aspartic acid and lysine closes the ring, which holds the His-D-Phe-Arg-Trp core recognised by every melanocortin receptor. N-terminal acetylation and norleucine in place of methionine shield the chain from oxidation and exopeptidases. Tryptophan is the most light-sensitive residue present, which is why the powder belongs in the dark.

Bremelanotide and Melanotan 2 sit roughly one mass unit apart (1025.2 against 1024.2 g/mol), so only a measured mass tells you which one is in the vial. Check that the mass spectrometry figure on the certificate matches 1025.2 g/mol and read the HPLC purity reported for that lot. Reports are filed in the COA library under the lot number on your label, and our guide on how to read a COA walks through each line.

Order PT-141 Near You and Store the Vial Correctly

AminoBlend runs no shopfront or pickup counter. Buy online and the parcel ships to every state and territory from stock held in Australia, so a lab buying peptides in Perth, Hobart or Cairns receives the same lot-tracked stock as one in Sydney. Orders paid before 3pm on a business day leave that afternoon, and the delivery information page lists transit times.

To reconstitute, let the vial reach room temperature, run the diluent down the inside of the glass and swirl gently until the solution turns clear, never shaking it. As a worked figure, 2 mL of bacteriostatic water in the 10 mg vial gives 5 mg per mL. The PT-141 reconstitution calculator handles other volumes, and how to reconstitute peptides sets out the aseptic method.

Sealed, the powder keeps at -20 °C in the dark. In solution it moves to the fridge at 2 to 8 °C, ideally divided into aliquots so the stock is not warmed and cooled again and again. The spray never goes in the freezer. Refrigerate it and finish it by the date printed on its label.

Other Names for PT-141

The same compound appears as PT-141, PT 141, PT141 and bremelanotide, and older papers call it a deamidated derivative of Melanotan 2. Every one of these names points to a single heptapeptide with CAS 189691-06-3 and the formula C50H68N14O10.

The receptor vocabulary helps as well. MC3R and MC4R are the melanocortin 3 and 4 receptors, MC1R is the melanocyte receptor, and alpha-MSH (alpha-melanocyte-stimulating hormone) is the natural ligand the whole family responds to. Papers usually class PT-141 as a melanocortin agonist with activity weighted toward MC3R and MC4R.

Shop PT-141 or Melanotan 2 by Research Question

Let the question decide. Melanotan 2 activates MC1R, MC3R, MC4R and MC5R broadly, which makes it a handy positive control and the usual pick for pigmentation work, with its 10 mg vial at $49. PT-141 is the better buy when a study centres on MC3R and MC4R and needs less MC1R signal in the background.

Neither analogue is perfectly selective, so groups separating MC4R from MC3R effects add receptor antagonists to the design. Order both in one cart for a clean structural pair, the same ring with one altered terminus. For upstream reproductive axis signalling, kisspeptin is the related reagent labs add most often.