Melanotan 1 Australia: Buy Melanotan 1 Online

Shop Melanotan 1 Peptide 10 mg With Lot Data and Chemical Identity

Order this vial when your melanocortin study needs selectivity for MC1R instead of broad activation across the receptor family. The 10 mg vial is held in Australian stock with a published certificate for each lot.

What Is Melanotan 1?

Melanotan 1, also known as afamelanotide, is a lab-made, longer-lasting copy of alpha-MSH, the natural hormone that tells pigment cells in skin to produce dark melanin. It keeps the hormone's full 13 amino acids in a straight chain and changes only two of them, which is enough to make it far tougher and more potent than the original.

How MC1R controls pigment

Melanocytes can make two kinds of melanin. Eumelanin is brown to black and absorbs ultraviolet light well; pheomelanin is red to yellow and offers much weaker protection. Which one a cell produces depends largely on MC1R. When alpha-MSH or an analogue binds that receptor, cyclic AMP rises, protein kinase A activates the transcription factor MITF, and MITF turns up the enzymes of the melanin pathway, tyrosinase first among them, steering production toward eumelanin. Human genetics shows the stakes. Common loss-of-function MC1R variants are behind most red hair and fair, freckle-prone skin that burns rather than tans, and carriers face a higher melanoma risk.

Pigment is not the whole story. Work in cultured human melanocytes, notably from Zalfa Abdel-Malek's group in Cincinnati, linked MC1R activation to faster repair of UV-induced DNA damage, an effect that does not depend on extra melanin. That is a large part of why researchers value the melanotan 1 peptide as a photoprotection probe rather than a pigment tool alone.

Origins and clinical testing

The analogue was first reported in 1980 in PNAS by Tomi Sawyer, Victor Hruby, Mac Hadley and co-workers in Tucson, Arizona. They found it resisted breakdown by serum enzymes and was 26 times as potent as alpha-MSH in an adenylate cyclase assay, with activity lasting far longer than the parent hormone. Beyond protoporphyria, clinical groups have tested afamelanotide in vitiligo. In a randomised trial published in JAMA Dermatology in 2015, Lim and colleagues compared narrowband UVB light alone with UVB plus afamelanotide in 55 participants; by day 168, repigmentation reached about 49 percent in the combination arm against 33 percent with light alone.

Our advice before ordering: check the MC1R status of the cells. Melanocyte and melanoma lines vary, and a line carrying loss-of-function variants will give a weak or flat response that reflects the cell, not the peptide. Characterise the receptor first, then run the concentration curve. The full Melanotan 1 versus 2 breakdown explains where the cyclic analogues differ.

Buy Melanotan 1 Peptide Online in Australia as the Selective MC1R Reference

Natural alpha-MSH breaks down within minutes, which limits its value in an experiment. Chemists at the University of Arizona kept its full 13 residue length but swapped the methionine at position 4 for norleucine and the phenylalanine at position 7 for its D form, creating an analogue that resists degradation and binds MC1R with high affinity. Its selectivity depends on that full-length chain. Trimming the sequence to a ring, as in Melanotan II, widens the receptor profile, so Melanotan 1 is often the agonist chosen for melanocyte lines that express MC1R alone.

The molecule later followed an Australian path, as Melbourne-based Clinuvel Pharmaceuticals developed afamelanotide into an implant approved overseas for the rare light sensitivity disorder erythropoietic protoporphyria. AminoBlend does not sell that medicine, and this vial is the peptide as a research reagent. Laboratories use it to study MC1R activation, the downstream cAMP signal and the switch to eumelanin in melanocyte culture and animal models. Shop it within our melanocortin peptides range.

Is Melanotan 1 Legal in Australia? Afamelanotide, Scenesse and This Vial

What you receive is a glass vial with a white cap and a pink and blue label, containing 10 mg of the linear peptide as a lyophilised white powder. Clinuvel's medicine is a different object entirely: a 16 mg controlled-release implant of afamelanotide designed to release the peptide over about two months. That implant earned approval under exceptional circumstances in the European Union in 2014, from the US FDA on 8 October 2019, and in Australia in October 2020, when the TGA registered it for preventing phototoxicity in adults with erythropoietic protoporphyria after a priority review.

So the compound has a registered medicine in Australia, but only one, with one indication and one dosage form. Scenesse is a prescription product placed under the skin by trained and accredited health professionals, and its registration does nothing to make Melanotan 1 a tanning product. Afamelanotide itself is a Schedule 4, prescription-only substance under the June 2026 Poisons Standard, the version in force in October 2026, and its index cross-references Melanotan I to that entry, so the schedule follows the substance whichever name is on the label. Melanotan II has its own separate Schedule 4 entry.

That combination explains the market. The only registered clinical form is that implant, while bench scientists studying MC1R in melanocyte cultures need weighed powder in milligram amounts, which the implant cannot provide. Research suppliers fill that gap. For anyone needing to buy Melanotan 1 in Australia for that kind of work, the 10 mg vial sits in AminoBlend's Australian stock, released only to adult buyers of at least 18, for in vitro laboratory use and never for human or veterinary use. Labs working on pigment pathways can browse the skin and hair research peptides category for related tools.

Order Melanotan 1 for Sale as a 10 mg Vial With Lot Tracking

Melanotan 1 comes in one fill, a 10 mg vial at $49, which keeps the cost under five dollars per milligram. At 1646.9 g/mol, 10 mg equals about 6.1 micromoles, enough for receptor binding curves and a run of melanocyte cultures completed within 28 days of reconstitution.

Buy all the vials a larger study needs at once to hold the work on a single lot and certificate wherever stock allows, which also simplifies comparison with published binding data because every curve traces back to one report. An age declaration of 18 or over is part of checkout, and the vial is supplied for laboratory research alone.

Buy Melanotan 1 in Stock With a Mass-Confirmed Lot Certificate

Melanotan 1 and Melanotan II are both white powders, so appearance cannot separate them, but mass can. The certificate should show a measured mass near 1646.9 g/mol for this linear peptide, far from the roughly 1024 g/mol of cyclic Melanotan II. The tryptophan at position 9 is the residue most prone to oxidation, so a well-stored lot should give a clean main HPLC peak, and mass data also catch oxidised tryptophan as a species 16 units heavier than the parent.

Find the report for your lot in the COA library, and use how to read a COA to interpret the figures.

Order Melanotan 1 Near You Online and Store the Powder Frozen

There is no shop or collection counter. Melanotan 1 is ordered online and shipped from Australian stock by tracked delivery to any state or territory, leaving the same day when the order is in before 3pm on a business day.

Allow the vial to reach room temperature, add the diluent slowly against the glass and swirl until the cake dissolves. Adding 1 mL gives 10 mg/mL, and 2 mL gives 5 mg/mL. The peptide dissolves readily in water, so vigorous shaking is never needed, and the peptide calculator does the arithmetic for any other figure.

Store the sealed vial at -20 °C away from light, which protects the tryptophan residue. After reconstitution, keep the solution at 2 to 8 °C in aliquots and use it within 28 days. The peptide storage guide explains why repeated temperature swings shorten shelf life.

Other Names for Melanotan 1 and Afamelanotide

This peptide is listed as Melanotan 1, Melanotan I, MT-1, MT1, afamelanotide and NDP-MSH, the short form of [Nle4, D-Phe7]-alpha-MSH, and 1980s literature often calls it the Nle-D-Phe analogue. Scenesse is the brand name of the registered implant, which is a medicine and not this product.

Receptor terms that travel with it include melanocortin 1 receptor, MC1R, alpha-melanocyte stimulating hormone, eumelanin and pheomelanin. They describe the biology under study, while CAS 75921-69-6 identifies the single compound behind every one of these names.

Order Melanotan 1 or Melanotan II to Separate MC1R Effects

Choose Melanotan 1 for a selective tool that works mainly through MC1R and leaves the central receptors largely aside. Choose Melanotan II for a cyclic, broad agonist of MC1R, MC3R, MC4R and MC5R, for example as a positive control across the family.

Running both under matched conditions shows which effects come from MC1R and which need the wider receptor set. Shop both together with ease, as each comes as a 10 mg vial at the same price, which makes a two-compound design simple to plan and budget. The Melanotan 1 vs 2 guide compares their structures in detail, and PT-141 is the related cyclic peptide studied mainly at central receptors.