Melanotan II Australia: Buy MT2 Peptide Online

Shop MT2 Peptide as a 10 mg Vial or 10 mL Spray With Lot Data

Order Melanotan II when you need one ligand that switches on most of the melanocortin family at once. It is the classic positive control for that receptor set, and both formats come from tested lots held in Australian stock.

What Is Melanotan 2?

Melanotan 2 is a lab-made ring-shaped peptide that mimics alpha-MSH, the natural hormone that signals through the melanocortin receptors, and it switches on four of the five receptors in that family at once. In research terms it is a master key for the melanocortin system rather than a tool for any single receptor.

The melanocortin system in brief

Alpha-MSH is processed out of a bigger precursor protein, pro-opiomelanocortin, in the pituitary, the hypothalamus and the skin. It acts on five related receptors, each with its own home. MC1R sits on melanocytes and controls the switch to dark eumelanin. MC2R, in the adrenal gland, responds only to ACTH. MC3R and MC4R are concentrated in the brain, where they help set food intake and energy expenditure, and MC5R is found mainly in exocrine glands. All five couple to Gs proteins, so activation raises cAMP inside the cell. Every natural melanocortin shares a four-residue core, His-Phe-Arg-Trp, and Melanotan II keeps that core inside its ring with the phenylalanine flipped to the D form, which strengthens and prolongs binding.

Where the MT2 peptide came from

The ring traces back to 1989, when University of Arizona chemists Fahad Al-Obeidi, Mac Hadley and Victor Hruby used molecular dynamics simulations to design cyclic lactam versions of alpha-MSH that were more potent and longer acting than the hormone. The lactam bridge, formed between an aspartate and a lysine side chain, locks the core into the turn shape the receptors prefer.

• Receptor coverage: subtypes 1, 3, 4 and 5, with MC2R left untouched.
• Second messenger: cAMP through Gs coupling.
• Landmark tool study: Fan, Cone and colleagues (Nature, 1997) used Melanotan II and the antagonist SHU9119 to show that central melanocortin signalling controls feeding in mice.

That 1997 paper points to the fact most people miss. Outside the tanning headlines, the Melanotan II peptide has earned its place in the literature as a central MC3R and MC4R agonist in rodent feeding and energy balance studies, not as a pigment tool. If pigment is your actual question, its spill-over onto brain and gland receptors becomes noise, and the linear, MC1R-leaning Melanotan 1 analogue gives cleaner data. Where Melanotan II shines is receptor mapping: pair it with a selective antagonist or a knockout line so that each response can be assigned to one receptor. The structural contrast between the two analogues is set out in our full guide to Melanotan 1 and 2.

Buy MT2 Peptide Online in Australia as the Broad Melanocortin Agonist

Melanotan II came out of the same University of Arizona programme as Melanotan 1 but took a different route. Rather than keep the full hormone, chemists cut the active core to seven residues and closed it into a ring through a lactam bridge between aspartate and lysine. Norleucine replaces the oxidisable methionine and a D-phenylalanine raises receptor affinity, giving a compact, stable peptide with nanomolar binding.

Laboratories buy it as a general activator of MC1R, MC3R, MC4R and MC5R, often paired with an antagonist such as SHU9119 to work out which receptor explains an effect. Only MC2R, the ACTH receptor, sits outside its range. Melanotan II has never been approved as a medicine anywhere, and the product sold here is a research reagent. Shop it alongside related ligands in our melanocortin peptides category.

Is Melanotan Legal in Australia? What Melanotan 2 Buyers Should Know First

Two physical formats sit under this listing. The 10 mg vial is a white freeze-dried plug under a white cap with a pink and blue label, holding peptide only. The 10 mL bottle is a ready-made solution behind a white pump actuator and silver collar, so there is nothing to reconstitute. Both contain the same cyclic heptapeptide, and both are tested as separate lots. Its linear relative, Melanotan 1, and the ring-sharing PT-141 are sold as their own products for receptor comparison work.

Is Melanotan legal in Australia? The TGA states that Melanotan II is a prescription-only (Schedule 4) medicine that has never been approved as a tanning agent, and that supplying it for tanning without a prescription is unlawful in any form, whether spray, tablet, injection or cream. It also cannot be advertised to the public, influencer posts included. In January 2025 the regulator warned that melanotan nasal sprays and other tanning products were being illegally promoted online, and it has since issued 27 infringement notices totalling $101,412 to a NSW individual over alleged supply of Melanotan II. As of October 2026 no Melanotan II product is registered on the ARTG. The contrast with Melanotan 1 is sharp: its pharmaceutical form, afamelanotide, was developed by Melbourne company Clinuvel and registered by the TGA in 2020 as the Scenesse implant for erythropoietic protoporphyria, a rare light-sensitivity disorder, which is no approval for tanning.

That leaves research supply as the only legitimate channel for anyone looking to buy Melanotan 2 in Australia or searching MT2 Australia stock. AminoBlend keeps both formats in Australian stock as receptor pharmacology reagents for in vitro work, sold to adults 18 and over, and neither is for tanning or any human or veterinary use. Read our Melanotan 1 vs 2 guide for the regulatory background, or compare the selective Melanotan 1 vial.

Order Melanotan II for Sale as a Vial or Spray With Lot Tracking

The 10 mg vial at $49 suits most first orders, because you choose the working concentration yourself and the dry powder keeps in the freezer until the study starts. The 10 mL nasal spray format at $59 arrives already in solution, removing weighing and mixing where several staff need one consistent pre-made stock, though it cannot be concentrated or diluted in place.

Buy the full number of vials for a longer project in one order so they share a lot and a certificate. Labs that need both a mapping tool and a selective comparator often add Melanotan 1 to the same parcel. Melanotan II is sold only to adults aged 18 and over, with age confirmed before the order is placed.

Buy Melanotan II in Stock and Check Its Mass on the Certificate

The identity check that matters most is mass. PT-141 is built on the same ring and differs only by a free carboxylic acid at the C-terminus where Melanotan II carries an amide, so the two sit about one mass unit apart and HPLC alone separates them poorly. Each lot certificate reports a measured mass that should match about 1024.2 g/mol, beside the HPLC purity figure and analysis date.

The tryptophan inside the ring is sensitive to oxidation, so a well-stored lot keeps a clean chromatogram, while a small satellite peak about 16 mass units heavier hints at poor storage history. The best Melanotan 2 peptide for any study is simply the lot whose certificate you have read and matched to your vial. Look up any lot in the COA library, and the guide to reading a COA explains the mass and purity columns.

Order Melanotan II Near You Online and Store Each Format Correctly

AminoBlend runs no shop or pickup desk, so both formats are ordered online and packed from Australian stock for tracked delivery to every state and territory. Orders placed before 3pm on a business day go out the same day.

For the vial, let it reach room temperature, run the diluent down the inside of the glass and swirl until the powder clears, since Melanotan II dissolves readily in water. As a reference, 5 mL in the 10 mg vial gives 2 mg/mL and 2.5 mL gives 4 mg/mL, while the peptide calculator covers any other volume.

Keep sealed vials at -20 °C and away from light to protect the tryptophan. Reconstituted solution goes to 2 to 8 °C in aliquots and should be used within 28 days. The spray bottle follows the storage directions and expiry printed on its own label, and because spray and vial lots are tested separately, record the lot code of whichever format you use. The peptide storage guide has more on shelf life.

Other Names for Melanotan II and MT-II

The compound appears as Melanotan II with Roman numerals, Melanotan 2, Melanotan-2, MT-II and MT2, and papers sometimes describe it by structure as a cyclic lactam analogue of alpha-MSH. Every one of these labels refers to the same ring and to CAS 121062-08-6, and none of the spellings reflects a change in sequence or quality.

Receptor vocabulary that travels with it includes melanocortin receptors 1, 3, 4 and 5, alpha-melanocyte stimulating hormone, agouti-related protein and the antagonist SHU9119. The linear peptide Melanotan 1 is a separate compound with its own product page.

Order Melanotan II or PT-141 Based on Receptor Focus

Choose Melanotan II for a broad activator of four receptors, useful as a positive control or for mapping the system. Choose PT-141 when your work centres on the central MC3R and MC4R receptors with less MC1R activity, since it shares the ring but ends in a free acid.

Shop Melanotan 1 instead when MC1R selectivity is the priority, as it is the linear alternative. The Melanotan 1 vs 2 comparison sets out the structural differences.