Thymosin Alpha-1 Australia: Buy Thymosin Alpha-1 Online

Shop Thymosin Alpha-1 Peptide in 5 mg and 10 mg With Full Lot Data

Order this reagent for immunology work on antigen-presenting cells and T cell maturation, choosing the fill that matches the length of your study. Both sizes share one synthesis specification and leave the warehouse only with a certificate.

What Is Thymosin Alpha 1 Peptide?

Thymosin alpha 1, often shortened to TA1, is a small immune signalling peptide, first found in the thymus, that researchers use to study how the innate sensors of infection switch on a T cell response. In lab terms it is a 28 amino acid fragment cut from a much larger parent protein, and the vials here are a synthetic copy of that fragment.

Where the peptide comes from inside the cell

The parent, prothymosin alpha, is one of the most acidic proteins in mammalian cells and lives mainly in the nucleus, where it is linked to chromatin remodelling and cell proliferation. It is made in lymphocytes and many other dividing cells, not only thymic tissue. In 2003 a Spanish team reported in the Journal of Biological Chemistry that a lysosomal asparaginyl endopeptidase (legumain) trims prothymosin alpha to release the alpha 1 fragment, which explains how a nuclear protein ends up as a secreted-style signalling peptide.

How Thymosin alpha 1 acts in research models

The receptor story centres on toll-like receptors, the pattern sensors that dendritic cells use to detect microbial material. In mouse and human cell work, the peptide has been reported to engage TLR9 on plasmacytoid dendritic cells and TLR2 on myeloid ones, which pushes those cells to mature, present antigen more effectively and release IL-12. IL-12 in turn steers naive T cells toward a Th1 profile, the arm of immunity aimed at viruses and intracellular bacteria.

Human trial data are larger than for most research peptides, and not all of it is positive. The TESTS trial, a double-blind phase 3 study across 22 Chinese hospitals published in the BMJ in 2025, randomised 1106 adults with sepsis to the peptide or placebo. Mortality at 28 days was 23.4 per cent against 24.1 per cent, with no significant difference in any secondary or safety outcome. An earlier and smaller multicentre sepsis trial, ETASS, published in 2013 with 361 patients, had reported 26.0 against 35.0 per cent mortality but missed statistical significance, so the larger study settled a question the first one left open.

Our practical warning for anyone using TA1 in dendritic cell or macrophage assays: bacterial endotoxin (LPS) triggers TLR4 and can drive IL-12 and maturation markers on its own. A trace of endotoxin in any reagent, peptide or buffer, can produce exactly the readout you are looking for. Run an endotoxin check on the working solution, or include a polymyxin B arm that neutralises LPS, before attributing a cytokine shift to the peptide. That one control decides whether a positive result will survive peer review.

Buy Thymosin Alpha-1 Peptide Online in Australia as a Defined Thymic Reagent

Allan Goldstein's group isolated Thymosin Alpha-1 from thymosin fraction 5, a calf thymus extract, and published its sequence in 1977. Later work traced it to prothymosin alpha, a nuclear protein expressed well outside the thymus. The chain is dense with aspartate and glutamate, which gives it a strong negative charge at neutral pH, and it contains no disulfide bridges.

For a laboratory, it answers one specific question. How does a single, fully defined thymic peptide change the way dendritic cells and lymphocytes respond to a challenge? Mechanistic studies point to TLR2 and TLR9 on dendritic cells, MyD88 and NF-kB signalling, and shifts in cytokines such as IL-12. As thymalfasin it is registered as a medicine in some countries, though not in Australia, and the vial supplied here is a research reagent only. Shop it with related tools in the immune peptides category.

Thymosin Alpha-1 in Australia: The Vials, the Thymalfasin Story and Local Status

Two fills are available, a 5 mg vial and a 10 mg vial, each holding the acetylated 28 residue chain as a white freeze-dried powder with no diluent in the box. The material is made by solid-phase synthesis rather than extracted from thymus, which is how the commercial medicine has been produced too. That medicine is thymalfasin, sold under the Zadaxin name by SciClone Pharmaceuticals, which won its first approval in China in 1995 for chronic hepatitis B and was later registered in around three dozen countries, most of them in Asia. It has never been approved by the US FDA.

So is Thymosin Alpha-1 legal in Australia as a reagent? The October 2026 Poisons Standard does not name thymosin alpha-1 or thymalfasin anywhere, so neither carries a schedule as of October 2026. Australians tend to know the word thymosin from the Essendon supplements case, in which the Court of Arbitration for Sport found in January 2016 that 34 players had been given thymosin beta-4. That is a separate actin-binding protein, the parent of the TB-500 fragment covered in our research guide, and the Poisons Standard places thymosin beta-4 in Schedule 4. Mixing up the two is easy when reading Thymosin Alpha-1 Australia search results, so check which chain a listing actually names.

Unscheduled is not the same as approved for therapeutic supply, which the TGA reserves for products on the Australian Register of Therapeutic Goods. Buy Thymosin Alpha-1 Australia stock from AminoBlend as a research reagent held in local inventory, sold for laboratory use to adults 18 and over and not for human or veterinary use. Labs pairing it with bioregulator work can add the Thymalin thymic complex to the same order.

Order Thymosin Alpha-1 for Sale in Two Sizes With Lot Tracking

The 5 mg vial at $59 fits pilot experiments, method development and short cytokine assays. The 10 mg vial at $89 brings the cost per milligram down and suits longer series or several plates run side by side, as long as the reconstituted solution is used within 28 days.

Buy every vial a study will consume in one order so they come from a single lot wherever stock allows and share one certificate, which keeps comparisons between runs clean. A 28 residue chain with an acetylated end needs careful solid-phase synthesis and purification, so each lot waits on the shelf until its results are in. Buyers confirm at checkout that they are 18 or older.

Buy Thymosin Alpha-1 in Stock With a Verified Purity Certificate

The two details most worth checking are the N-terminal acetyl group and the full length. A truncated chain or one without its acetylation can still produce a neat HPLC peak, but its measured mass falls short of about 3108 Da. Each certificate reports the mass spectrometry result next to the HPLC purity figure and the date of analysis.

Match the lot code on your vial to its report in the COA library, and follow the guide on reading a COA to find each value on the page.

With so many acidic residues, the sequence elutes early on a reversed-phase column and shows one dominant peak after a clean synthesis, while extra shoulders usually signal deletion sequences. Setting two lot certificates side by side is the fastest way to confirm consistency over a long project.

Order Thymosin Alpha-1 Near You Online and Keep the Powder Cold

Every order runs through the online store, since there is no retail counter or click-and-collect service. Stock is held in Australia, and orders placed before 3pm on a business day leave that day with tracked delivery to metropolitan and regional addresses.

Let the vial reach room temperature before opening, add diluent drop by drop against the glass and roll it gently, because foam means it has been over-mixed. Adding 1 mL to the 5 mg vial gives 5 mg/mL, while 2.5 mL gives 2 mg/mL. Use the peptide calculator for any other volume or for the 10 mg fill.

Unopened powder lasts longest at -20 °C, dry and dark. Reconstituted solution belongs at 2 to 8 °C, split into aliquots so the main vial is opened as rarely as possible, and should be finished within 28 days. Each step is covered in the reconstitution guide.

Other Names for Thymosin Alpha-1 and Thymalfasin

Catalogues and papers use several labels for this chain, including Thymosin Alpha-1, thymosin alpha 1 without the hyphen, TA1 and thymalfasin. Zadaxin is the brand name of the registered medicine, which AminoBlend does not sell.

Related immunology terms include prothymosin alpha (the precursor), thymosin fraction 5 (the original extract), toll-like receptors, plasmacytoid dendritic cells and Th1 polarisation. None of these names marks a different molecule, and CAS 62304-98-7 links them all to one sequence.

Order Thymosin Alpha-1 or Thymalin to Match Your Immune Study

Pick Thymosin Alpha-1 when you need a single defined sequence with a fixed mass that compares directly with the international literature. Pick Thymalin when the project follows the Russian bioregulator tradition, where the material began as a thymic polypeptide complex and most published work came from a small group of institutes.

Take care with TB-500. It shares the thymosin name but derives from thymosin beta-4, an actin-binding protein with no structural link to the alpha-1 chain, and it is studied in cell migration and tissue repair rather than immune signalling.

Shop both thymic products in one parcel and keep each on its own certificate, which makes it simple to report every reagent's lot in a methods section.