5 Amino 1MQ Australia: Buy 5-Amino-1MQ Online

5-Amino-1MQ 50 mg Lot Data and Chemical Identity

Order 5-Amino-1MQ for work on NNMT, the methyl pool and NAD+ salvage. One 50 mg fill goes a long way at micromolar working concentrations, and each lot is traced from test to label.

What Is 5-Amino-1MQ?

5-Amino-1MQ is a small laboratory compound that blocks NNMT, an enzyme that uses up nicotinamide inside cells, and it is studied to see how fat and muscle cells behave when that enzyme is switched off. Searchers often call it the 5 amino 1MQ peptide, but it is a single ring-based molecule rather than a chain of amino acids, and that distinction shapes how it behaves in an experiment.

To see why anyone would want to block NNMT, follow the nicotinamide. Every time a cell spends NAD+ on signalling enzymes such as sirtuins or PARPs, nicotinamide is left over. Most of it goes back through the salvage pathway, where the enzyme NAMPT turns it into NMN and then into fresh NAD+. NNMT competes for the same pool. It tags nicotinamide with a methyl group taken from SAM, the cell's main methyl donor, and the methylated product cannot be recycled. So an active NNMT drains two pools at once: the nicotinamide that would have rebuilt NAD+, and the SAM that supplies methyl groups for DNA and histone marks.

How the idea moved from a gene to a compound

The target came first. In 2014 a team led by Barbara Kahn at Beth Israel Deaconess and Harvard published a Nature paper showing that NNMT expression rises in the white fat and liver of obese and diabetic mice, and that knocking the gene down in those tissues protected mice from diet-induced obesity by raising energy expenditure. Adipose SAM and NAD+ both went up when NNMT was suppressed. That result gave medicinal chemists a reason to look for a drug-like inhibitor, and the Galveston methylquinolinium series followed. In the 2018 obese-mouse study, treated animals lost body weight and white fat over 11 days with no change in food intake, and their fat cells were smaller, a pattern the authors read as increased fat use rather than reduced eating.

Our practical advice is to check NNMT before buying anything else. Expression varies enormously between cell types and even between undifferentiated and differentiated cultures of the same line, and an inhibitor added to cells with little NNMT will produce a flat result that says nothing about the compound. Confirm expression by western blot or qPCR first. Then measure 1-methylnicotinamide, the enzyme's direct product, by LC-MS as your engagement marker. NAD+ levels drift with culture density and medium, so they make a weak primary readout on their own.

Buy 5-Amino-1MQ Online in Australia, a Small Molecule Rather Than a Peptide

Shop it beside research peptides because it comes in the same style of vial, but chemically 5-Amino-1MQ is a compact aromatic cation with no amino acids at all. Its small size and permanent positive charge still let it cross cell membranes, which is the property that first drew researchers to the methylquinolinium series. A group at the University of Texas Medical Branch published the key work in Biochemical Pharmacology in 2018, describing membrane-permeable NNMT inhibitors in diet-induced obese mice.

The lab question is direct. What happens to a cell's methyl balance and NAD+ recycling when NNMT is blocked? Reports of 5 amino 1MQ benefits in that literature are preclinical observations in cells and mice, and the vial is a reagent for that work, with no published human trials and no connection to any medicine.

Buying 5 Amino 1MQ in Australia: The Vial, Its Origins and Its Status

What is 5-Amino-1MQ in physical terms? A single vial with a green flip-off cap and a white label, holding 50 mg of dry solid salt. There is no liquid, no peptide and no carrier blended in. Because the counter-ion makes up part of the weighed mass, the certificate for each lot names the salt form, and that figure, not the bare cation, is the one to use when converting milligrams into a molar stock.

The compound comes from academic medicinal chemistry rather than a drug company pipeline. Researchers at the University of Texas Medical Branch in Galveston explored a series of methylquinolinium compounds as NNMT inhibitors, and 5-amino-1-methylquinolinium was the analogue they carried forward into cell and mouse studies. It has not been approved as a medicine by any regulator we could find, and as of October 2026 we found no product containing it on the Australian Register of Therapeutic Goods. That means there is no prescription version, no pharmacy supply and no TGA evaluation behind it.

Why 5-Amino-1MQ for Sale in Australia Comes From Research Suppliers

With no medicine to buy, the only source is a chemical supplier selling it as a laboratory reagent, which is how research groups obtain it. AminoBlend keeps the 50 mg vial in Australian stock, available to order online by adults 18 and over, and supplies it strictly for in vitro work, never for human or veterinary use. Labs that buy 5-Amino-1MQ in Australia often add a second small molecule from the same metabolic group, such as the ERR agonist SLU-PP-332, so that an enzyme inhibitor and a nuclear receptor agonist can be compared on one plate.

Shop 5 Amino 1MQ in One 50 mg Vial With Lot Tracking

Buy the single size that covers nearly every buyer. NNMT inhibitor studies in culture run at micromolar concentrations, and a molecule of about 159 g/mol packs a large number of micromoles into 50 mg. At $79 the vial costs $1.58 per milligram, and one fill usually outlasts a full programme of cell work.

Order the vials you need for multi-site studies or a long screen in one checkout from one lot wherever stock allows, so every arm traces back to a single certificate. Sales are open to adults 18 and over only.

Because the compound is a stable small molecule, the dry vial keeps well, which makes it practical to hold one sealed reserve vial from the same lot for replication work later in the year.

Order 5-Amino-1MQ in Stock With Structure, Purity and Lot Certificate

The structure is a quinoline ring methylated on its nitrogen, which gives the permanent positive charge, with an amino group at position 5 that sets its fit in the NNMT active site. It is supplied as a salt, so the weighed mass includes a counter-ion as well as the active cation.

When reading the certificate, look for the cation mass near 159 on the mass spectrum, the stated salt form and the HPLC purity for your lot. All reports sit in the COA library under the lot code on the label, ready to download before or after purchase. A lot that misses its specification is withheld from sale rather than discounted.

Order 5 Amino 1MQ Near You, Then Dissolve and Store It

AminoBlend sells online only, dispatching from stock kept in Australia to any address in the country, from inner-city labs buying peptides in Newcastle to regional campuses. Pay before 3pm on a business day and the vial goes out that day, and the delivery information page covers the services.

Buy a solvent separately, as none is supplied. Many labs dissolve the compound in bacteriostatic water, letting the vial reach room temperature first, then adding the liquid and swirling until clear. Five mL in the 50 mg vial gives 10 mg/mL, and the general concentration calculator handles other volumes. Before converting to molarity, use the full salt mass from the certificate rather than the cation alone, or every working dilution will be off.

Keep the sealed vial dry and dark at -20 °C for long holding. Once dissolved, store the stock at 2 to 8 °C, protected from light, and use it within 28 days, leaving whatever you do not need yet as dry solid.

Other Names for 5-Amino-1MQ

The compound is written 5-amino-1MQ, 5-amino 1MQ, 5amino1MQ and 5 amino 1 MQ, and spelled out as 5-amino-1-methylquinolinium or 5-amino-1-methylquinolin-1-ium. Salt forms add a suffix such as iodide. Some shops list it as 5 amino 1MQ peptide, although it has no peptide bonds.

The enzyme it targets is nicotinamide N-methyltransferase, abbreviated NNMT. That enzyme moves a methyl group from S-adenosylmethionine (SAM) onto nicotinamide, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH). NNMT is expressed at high levels in liver and adipose tissue, which is where most of the preclinical 5-Amino-1MQ work has been done.

Shop 5-Amino-1MQ or NAD+ for Your Design

They work at two ends of one pathway. 5-Amino-1MQ blocks the enzyme that diverts nicotinamide away from recycling, while NAD+ is the coenzyme itself, added directly. Order 5-Amino-1MQ to study what happens when the salvage route is protected, NAD+ when you need the cofactor in the medium, and both to compare the two approaches in one design.

For a receptor-level angle on the same metabolic programmes, SLU-PP-332 is another small molecule, an agonist of the estrogen-related receptors, while AOD-9604 offers a peptide route into fat cell metabolism. Either one sits well beside this NNMT inhibitor in a single order.