Semax Peptide Australia: Buy Semax Online or as a Nasal Spray

Shop Semax Peptide as a 10 mg Vial or 10 mL Nasal Spray With Full Lot Data

Name	Semax
Sizes and prices (AUD)	10 mg vial at $59, 10 mL nasal spray holding 10 mg at $69
Sequence or structure	Met-Glu-His-Phe-Pro-Gly-Pro, the ACTH 4 to 7 fragment followed by Pro-Gly-Pro
Length	7 amino acids
Molecular formula	C37H51N9O10S
Molar mass	813.9 g/mol
CAS number	80714-61-0
Form	Vial holds freeze-dried powder under a flip-off cap. Spray holds a 1 mg/mL solution in a 10 mL pump bottle
Testing	Identity by mass spectrometry and purity by HPLC on every vial and spray lot, each with a certificate
Contents	One 10 mg vial with no diluent (bacteriostatic water sold separately), or one spray bottle containing 10 mg in 10 mL
Storage	Sealed vial at -20 °C, away from light and air. Spray and mixed vial at 2 to 8 °C
Availability	In stock
Use	Laboratory in vitro research only

Shop Semax as powder when you want full control of concentration, or as a spray that mirrors the intranasal designs common in its literature. Both formats hold 10 mg, leave from Australian stock and carry their own lot certificate.

What Is Semax Peptide?

Semax is a short synthetic peptide made from a fragment of the stress hormone ACTH, kept for its effects on brain signalling while leaving out the hormone's action on the adrenal glands. Researchers mainly use it to study how nerve cells regulate BDNF, a growth factor that supports neuron survival and the strengthening of synapses.

From a pituitary hormone to a brain peptide

ACTH is a 39-residue hormone released by the pituitary that tells the adrenal cortex to make cortisol. In the 1960s and 1970s, David de Wied's group in Utrecht showed that small pieces of ACTH, notably the 4 to 10 region, changed learning and avoidance behaviour in rats without triggering any steroid release. That work helped establish the idea of neuropeptides: hormone fragments acting on the brain in their own right. Moscow researchers led by Nikolai Myasoedov and Igor Ashmarin took the shorter 4 to 7 segment and capped it with a proline-rich tail so it would survive longer in tissue.

A detail worth knowing: the classic melanocortin receptor binding core is His-Phe-Arg-Trp, positions 6 to 9 of ACTH. Semax keeps only the His-Phe half of that motif, which is one reason its activity is not explained by simple melanocortin receptor agonism and why its mechanism is still debated.

What the BDNF studies found

The most cited paper is a 2006 Brain Research study by Dolotov and colleagues. After a single intranasal dose of 50 µg/kg, rats showed changes in the hippocampus that peaked at different sizes depending on what was measured:

• exon III BDNF mRNA up about 3-fold
• TrkB receptor mRNA up about 2-fold
• TrkB tyrosine phosphorylation up 1.6-fold
• BDNF protein up 1.4-fold at most

The treated animals also produced more conditioned avoidance responses in a learning task, which tied the molecular change to behaviour in the same experiment.

The list above carries our main practical point. The transcript signal is roughly twice as large as the protein signal, and it was reported for one specific BDNF transcript. The BDNF gene has several promoters, each producing a different first exon, and primers that pick up total BDNF mRNA can dilute an exon-specific change into noise. If a Semax experiment uses qPCR, design exon-specific primers alongside a total BDNF assay, and confirm with protein measurement before calling a result positive or negative.

Buy Semax Online in Australia, the ACTH 4 to 7 Analogue

Buy Semax online in Australia and you are ordering a peptide designed at the Institute of Molecular Genetics in Moscow, a Russian Academy of Sciences laboratory. Its head, Met-Glu-His-Phe, copies positions 4 to 7 of adrenocorticotropic hormone, a region tied to neurotrophic activity rather than to the hormone's adrenal effects. The Pro-Gly-Pro tail slows peptidase degradation, so the seven-residue chain lasts longer than the native fragment would.

Research teams mostly order Semax to measure brain-derived neurotrophic factor and its receptor TrkB in the rat hippocampus and cortex. Others use it in middle cerebral artery occlusion models to follow genes tied to inflammation and new vessel growth, while transcriptomic studies and work on dopamine and serotonin systems fill out the rest of the literature. The question it answers is how a hormone fragment with no hormonal activity can shift neurotrophin expression. Shop it within our nootropic peptides range, where it is listed as a research reagent and not a medicine.

Buying Semax in Australia: What You Receive and Its Status

Order the vial and you get a 10 mg plug of white lyophilised Semax under a teal flip-off cap; the spray version is a pump bottle filled to 10 mL that carries the same 10 mg already dissolved. Semax first appeared in the scientific literature in 1991, and unlike most peptides sold for research it went on to become a prescription medicine in Russia. It is also on the Russian List of Vital and Essential Drugs approved by the Russian government in late 2011. Outside Russia and a few neighbouring markets it has not been evaluated or approved as a medicine, including in the United States, and independent randomised trials in Western countries are still lacking.

Where Semax sits under Australian rules

Is Semax legal in Australia? As of October 2026 the Poisons Standard does not name it, and our search of the October 2026 instrument for Semax returned no entry, so it carries no schedule of its own. A Russian registration gives it no standing here either. Therapeutic supply in Australia depends on inclusion on the Australian Register of Therapeutic Goods, and the TGA has listed unapproved peptide products among its compliance priorities. For that reason, Semax Australia searches lead to research reagent suppliers instead of pharmacies.

AminoBlend keeps both the vial and the Semax nasal spray in local inventory, so you can buy Semax Australia stock as a research reagent for laboratory use. Only adults 18 and over can order, and the peptide is not intended for any human or veterinary use. The peptide reconstitution guide covers preparing the powder, and the tuftsin-based Selank vial and spray share the same Pro-Gly-Pro tail for paired comparisons.

Order Semax Peptide for Sale as Powder or as a Ready Spray

Order the 10 mg vial at $59, or $5.90 per milligram, when you need powder to dissolve at the exact strength your protocol calls for, which suits dilution series and cell work. The 10 mL nasal spray at $69 carries the same 10 mg already in solution at 1 mg/mL behind a pump actuator. At $6.90 per milligram, the extra $10 pays for preparation and the bottle rather than for more peptide. The spray saves bench time, but its concentration is fixed.

Buy every unit for a study in one order and they ship from a single lot wherever stock allows with one certificate, which keeps the notebook simple when replicates are compared later. For intranasal panels, the Spray Research Kit at $179 combines the Semax, Selank and DSIP sprays. What makes the best Semax peptide for a lab is not a label claim but a matching lot number, a published certificate and cold storage from the day the parcel lands. Semax is sold only to adults 18 and over.

Buy Semax With the Structure, Purity and Lot Certificate on File

The methionine at position 1 is the residue to watch. It can oxidise when exposed to air and light, and on a certificate that shows up as a companion peak 16 daltons heavier than the parent mass. Histidine and phenylalanine give the chain aromatic character and clean UV detection on HPLC.

Shop with the paperwork in view. A sound certificate shows a measured mass that matches 813.9 g/mol, one main HPLC peak and a purity result tied to the lot on your label. Every Semax certificate, for powder and spray alike, sits in the COA library.

Order Semax Online for Delivery Near You and Store It Cold

Semax cannot be collected from a shop. AminoBlend sells through this website only, with no premises open to the public, and ships across Australia from local stock. Order before 3pm on a business day and the parcel is dispatched the same day, while the delivery page explains tracking and timing. Buyers after research peptides in Canberra are served from that same stock.

To protect the methionine, keep the vial sealed in the freezer until the day you need it. Let it reach room temperature, then add fresh bacteriostatic water slowly down the glass. Adding 4 mL to the 10 mg vial gives 2.5 mg/mL, a handy stock for further dilution, and the peptide calculator covers any other volume.

The sealed vial stays at -20 °C, away from light. Once mixed, store it at 2 to 8 °C in tightly closed aliquots with as little headspace as practical. The spray bottle also goes in the fridge on arrival.

Other Names for Semax

Semax is written MEHFPGP in one-letter code and Met-Glu-His-Phe-Pro-Gly-Pro in full. Russian papers often describe it as an ACTH 4 to 7 fragment prolonged by Pro-Gly-Pro, or as an ACTH 4 to 10 analogue, because it was modelled on that longer fragment. Related terms in its literature include BDNF, TrkB and melanocortin peptides. Shop under any of these labels and you receive the same 813.9 g/mol heptapeptide registered under CAS 80714-61-0.

Order Semax or Selank for a Matched Pair

Buy Semax when your study is about neurotrophins, ischaemia models or dopamine and serotonin systems, since most of its literature sits there. Choose Selank when the focus is GABA-related gene expression, enkephalin metabolism or cytokines. The two share a length of seven residues and the Pro-Gly-Pro tail, so any difference in response traces back to the head sequence, ACTH-derived in one and tuftsin-derived in the other.

For sleep-related designs, DSIP is the third peptide offered in the same spray format.